The Search for Autoimmune-Associated Epilepsy Continues—Are We Getting Closer to Our Target?

Why are we not getting any closer to preventing suicide?

Are we getting our money's worth?

Treating epilepsy in tuberous sclerosis with everolimus: getting closer.

Commentary Tuberous sclerosis complex (TSC) is an autosomal dominant disorder characterized by hamartomas in any organ system, especially the brain, retina, heart, skin, kidney, lung, and liver. Neurological manifestations are responsible for most disability , and include cognitive impairment and subependymal giant cell astrocytomas (SEGAs), but epilepsy is the most common problem, occurring in...

Getting closer to p-selectin.

Inflammation is recognized for its important role in the pathophysiology of atherosclerosis (1 ). However, the use of genetic association studies to dissect the impact of inflammatory genes on vascular disease is challenging because of the relatively small effects expected for common variants and the difficulty of identifying surrogates that best reflect underlying disease processes. In this is...

Role of the SOCS in monocytes/macrophages-related pathologies. Are we getting closer to a new pharmacological target?

The suppressors of cytokine signalling (SOCS) are proteins that restrict the functions of cytokines. Since their discovery, the state of knowledge regarding the SOCS is being regularly updated. One of the aspects of their importance concerns the immune system and its elements. Macrophages are one of the key cell types expressing SOCS and subsequently influence multiple biological processes. Pre...